Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/275915576?client_source=feed&format=rss
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Wednesday, January 9, 2013
VIDEO: Governor Calvo "Wholeheartedly Embraces" Speaker Won ...
Last Updated on Tuesday, 08 January 2013 21:01 Written by Clynt Ridgell Tuesday, 08 January 2013 18:17
Guam News - Guam News
Guam - Governor Eddie Calvo says he accepts Speaker Judi Won Pat's offer to improve the lines of communication between the governor's office and the legislature.
During her inaugural address Speaker Won Pat urged the government as a whole to improve it's lines of communications. She specifically called upon the governor to work with her in improving communications between each other.
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"I wholeheartedly embrace again the offer made by the speaker for closer dialogue and communication I think that's important,? said Governor Calvo adding,"I look forward to working with the speaker and other chairs of other important committees of this legislature again in bridging whatever gaps we may have had in the past."
The Governor agrees with the Speaker and says this is a new year and a time to re-engage and improve upon the communication between government leaders and entities.
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Ned Wertimer: 1923-2013
Ned Wertimer, a prolific character actor who perhaps was best known for playing Ralph the Doorman for 11 seasons on the CBS sitcom The Jeffersons, has died. He was 89.
Wertimer died Jan. 2 at the Sherman Village Health Care Center outside of Los Angeles from complications following a fall in his Burbank home in late November, his longtime manager, Brad Lemack, said Tuesday.
Wertimer had more than 100 TV credits in his career as he guest-starred on such series as Gunsmoke, McMillan & Wife, Car 54, Where Are You?, The Debbie Reynolds Show, The Mary Tyler Moore Show, WKRP in Cincinnati, Mork & Mindy, He & She and Family Law.
PHOTOS:?Hollywood's Notable Deaths of 2012?
On film, he played stockbroker Fred Cates in Lucille Ball?s Mame (1974) and had roles in Santa Claus Conquers the Martians (1964), The Impossible Years (1968), The Strongest Man in the World (1975), The Pack (1977) and Pirates of the Caribbean: At World?s End (2007).
Wertimer?s character of the money-hungry doorman Ralph Hart was introduced during a 1975 episode of All in the Family titled ?The Jeffersons Move on Up.? On the Norman Lear spinoff, Ralph was always looking for a tip from the increasingly annoyed tenants of the luxury high-rise Colby East building in Manhattan.
Wertimer appeared in 51 of the 253 episodes of?The Jeffersons, which was one of the longest-running sitcoms in TV history.
Wertimer was born in Buffalo, N.Y., on Oct. 27, 1923. After serving as a pilot in World War II, he attended the University of Pennsylvania?s Wharton School and received a degree in business administration.
While at school, Wertimer was active in the Mask and Wig Club, an all-male musical troupe founded in 1889. He had major roles in its 1947 production of Juleo and Romiet, playing Lady Montague, and in the 1948 production of Alaska Right Away, as Senator Forghorn.?
Wertimer soon found success on Broadway. He was an assistant stage manager and castmember in Texas L?il Darlin?, a Robert Emmett Dolan/Johnny Mercer musical that opened in November 1949, and he appeared in Garson Kanin?s The Live Wire, which opened in August 1950. ?
In New York, Wertimer also began to get roles in the new medium of television, appearing in many of the popular shows of the era. He became a regular guest on the children?s series The Shari Lewis Show, which highlighted his natural gifts for mimicry and improv.
In 1961, Wertimer replaced Paul Lynde in the Tony Award-winning production of Bye Bye Birdie. He also worked in numerous national touring and stock productions of plays and musicals, including Brigadoon, Hatful of Rain, Witness for the Prosecution, A Man for All Seasons, Cyrano de Bergerac, Annie Get Your Gun, Bells Are Ringing, Will Success Spoil Rock Hunter? and, much later, The Best of The Jeffersons, a re-creation of three episodes from the TV series starring its original cast.
During the mid-1960s, Wertimer moved to Los Angeles to continue his career.
Wertimer was ?involved in AFTRA and SAG?s union contract negotiations over the years and served as a dedicated, longtime member of the board of directors of the AFTRA SAG Federal Credit Union.
Survivors include his wife,?Skyne, professor emerita at California State University Long Beach; his sister-in-law Eleanor; and a niece and three nephews. Services will be private.
Source: http://www.rottentomatoes.com/m/1926615/news/1926615/
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Friday, January 4, 2013
The Best Health And Fitness Apps And Gadgets For Your New ...
[unable to retrieve full-text content]With a recent further of a Fitness Trainer app, Azumio is looking to turn a mobile, variable personal tutor and health-tracker that allows we to strech your aptness goals yet ever going to a gym. [Check out a coverage here.] ...
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Canonical?s Ubuntu Phone OS Aims To Steal Everyone?s Customization-Loving Customers
The odds are stacked against Canonical's late-comer Ubuntu phone OS. But by seducing hardcore mobile users who love to customize, it could could box out Microsoft and pull lucrative customers away from Android and iOS. Tinkerers buy high-end devices, pay for apps, and attract premium advertisers. So if Ubuntu mobile gains traction, it could earn solid revenue and win the mobile bronze medal.Source: http://feedproxy.google.com/~r/Techcrunch/~3/s944D5xUTtg/
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Entrepreneurs, Business Owners & Professionals Can Ask or ...
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Quora members can ask or answer urgent questions in realtime.
In November,?Quora?made its question and answer site even more valuable to time-sensitive information seekers with a new addition to its ?Ask to Answer? feature. Members can see when people who are knowledgeable about a question are ?Online Now? and available to answer immediately.
?One of the most amazing experiences on Quora is getting a great answer quickly. Fast answers are magical ? they satisfy your curiosity and help you make informed decisions. Fast answers are especially valuable when you are mobile and have questions that need answers right now.? -Joel Lewenstein, Quora Product Designer
For those not familiar with Quora, the?Palo Alto-based tech startup is a hybrid between crowdsourced online encyclopedia, Wikipedia, question and answer site, Yahoo! Answers, and micro-blogging social network, Twitter. Unlike other question and answer sites that are overrun by spam and unreliable information, Quora forces new members to register using their real names.
The resulting transparency creates a sense of accountability, responsibility and self-policing through up-and-down voting of answers.?This same ?quality control? of answers gives entrepreneurs, business owners and other professionals an opportunity to build up their reputation as a thought leader within their industry.
While some recommend using Quora to source content for their own site, the fact is that Quora ranks well with Google, can drive conversions and leads, and is a great resource for information and professional networking.
For more small business resources, follow?Firmology?on?Twitter?or?LinkedIn.
To contact the writer on this story: Philip Nowak in Chicago at philip.nowak@firmology.com. Please?contact us?if you?d like to?submit a small business innovation story or small business tech startup, product or service.
Philip Nowak is the founder of Firmology, a?small business news?and information media company focused on helping small business owners grow their business through technology and innovation.?You can find Philip on?Google+,?Twitter?and?LinkedIn.
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Scientists sequence genome of pathogen responsible for pneumocystis pneumonia
Wednesday, January 2, 2013
Scientists have sequenced the genome of the fungus Pneumocystis jirovecii, an advancement that could help identify new targets for drugs to treat and prevent Pneumocystis pneumonia, a common and often deadly infection in immunocompromised patients. The study will be published on December 26, 2012 in mBio?, the online open-access journal of the American Society for Microbiology. The organism cannot yet be isolated and grown for study in the laboratory, so details about Pneumocystis pneumonia, the biology of P. jirovecii, and its pathogenicity are hard to come by. The genome sequence represents a wealth of new information for doctors and researchers tackling this disease.
Pneumocystis pneumonia is an opportunistic infection that strikes most often in individuals with diminished immune systems. The corresponding author of the study in mBio?, Philippe Hauser of the Centre Hospitalier Universitaire Vaudois and University of Lausanne, in Switzerland, says the disease gained importance in the 1980s.
"Recognized first among malnourished infants, P. jirovecii pneumonia became a public issue with the advent of the HIV epidemic," says Hauser. Today, the disease most commonly affects HIV-infected persons who are unaware of their status as well as solid organ transplant recipients and patients with hemato-oncologic or autoimmune diseases. Since the organism cannot be grown in the lab for study, researchers have long made do with studying P. jirovecii's lab-friendly relatives, species that infect animals and plants, in order to explore the secrets of the human disease.
"It is obviously better to study [P. jirovecii's] genes rather that those of Pneumocystis species from animal models. The genome has both medical and evolutionary interests for the scientific community," says Hauser.
Under normal circumstances, scientists sequencing the genome of a microorganism simply extract DNA from thick cultures of cells they grow in the lab. Since they were unable to grow P. jirovecii cells for their genomic DNA, Hauser and his colleagues took a different approach. They took a sample of bronchoalveolar lavage fluid from an individual infected with Pneumocystis pneumonia, then concentrated the P. jirovecii cells using immuno-precipitation and created copies of the DNA in the sample using a technique called random DNA amplification. This mixture of DNA strands, from P. jirovecii, human, and other microbes from the lungs of the infected patient, was then sequenced using high throughput technologies.
According to Hauser and his colleagues, the fact that the sequence data represented DNA from many different species created the biggest challenge they faced. "The major challenge of the study was the in silico sorting of the reads out of a mixture representing the human host and different organisms present in the lung microbiome," he says. This challenge was met through a collaboration with Marco Pagni of the Vital-IT group of the SIB Swiss Institute of Bioinformatics, who provided indispensable expertise and infrastructure.
Once the sorting task was accomplished, the researchers assembled the sequences into a genome and attempted to identify the functions of P. jirovecii's genes. This is the first time scientists have assembled the genome of a fungus from a mixed pool of DNA from a single source, often called a metagenome. Their analyses reveal a surprising fact: P. jirovecii is a parasite that must live within the human body to survive.
P. jirovecii lacks the genes necessary for creating some of the essential ingredients of life, a hallmark of obligate parasites, organisms that must rely on another creature for sustenance. "It implies that they need their host to provide these molecules. Thus, this has been quite an important finding which implied that human beings represent the reservoir of this pathogen," says Hauser. This is useful information, since it means that people are the only significant source of the organism and that both infected people and healthy carriers represent the only control points for limiting the spread of the disease.
The genome also shows that P. jirovecii apparently lacks the ability to make toxins and virulence factors, molecules that enable a microbe to invade and take advantage of its host. This makes sense, since P. jirovecii does not cause disease in healthy people, but only runs out of control when it is not confronted with an immune response.
In the study of infectious disease, access to the genome of a pathogen provides new information that can be pivotal in combating the diseases is causes. The hope is that the genome of P. jirovecii will lead to new advances in therapies for those suffering from Pneumocystis pneumonia. The current drugs of choice for treating Pneumocystis pneumonia are antifolates, but certain isolates of P. jirovecii have already developed resistance to antifolates, an ability that is very likely to spread. Now that the genome of P. jirovecii is assembled and available to researchers all over the world, scientists can tease out clues about the organism that will help identify targets for some badly needed new drugs.
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American Society for Microbiology: http://www.asm.org
Thanks to American Society for Microbiology for this article.
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